biochemistry

Tissue-specific oncogenic activity of KRAS A146T

*KRAS* is the most frequently mutated oncogene. The incidence of specific *KRAS* alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant KRAS proteins. We …

Toxoplasma gondii disrupts $\beta1$-integrin signaling and focal adhesion formation during monocyte hypermotility

The motility of blood monocytes is orchestrated by the activity of cell-surface integrins, which translate extracellular signals into cytoskeletal changes to mediate adhesion and migration. *Toxoplasma gondii* is an intracellular parasite that …